why columbia has a crown
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WHAT WE DO:
We study the earliest steps of human development from the zygote to an adult functional cell to learn fundamental principles about development and cell differentiation.
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Join us to figure out some important challenges:
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Disease Modeling and Cell Therapy for Diabetes. Understanding metabolic disorders using stem cells.
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Understanding genome stability and preventing abnormalities in early development. See why in Nature.
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Physiological function of late replicating fragile sites. Read why here.
The Egli lab is located in New York City, United States.
Our most recent published work:
​Discover how embryos begin to organize their genome at the very beginning of life.
​PhD Student Shuangyi Xu and postdoctoral fellow Ning Wang discover that embryos establish a pattern of DNA replication in the first cell cycle, concordant with compartmentalization. This also shapes the stability and instability of specific genomic regions:
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility. Xu, Wang et al. Nat Comms 2024
and:
Genome organization and stability in mammalian pre-implantation development
Xu, Egli et al. DNA Repair 2024
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for more studies, see people profiles